RLIM enhances BMP signalling mediated fetal lung development in mice

Published: Dec 28, 2018
Abstract
RLIM, also called RNF12, is an X-linked E3 ubiquitin ligase. It is a pleotropic protein acting as a negative regulator of LIM-homeodomain transcription factors and of SMAD7, an antagonist of the BMP and TGFβ pathways. Mutations in RLIM are associated with variable congenital malformations in human. The molecular mechanism causing these malformations is still poorly understood. In this study, we used a conventional knockout (KO) mouse model to...
Paper Details
Title
RLIM enhances BMP signalling mediated fetal lung development in mice
Published Date
Dec 28, 2018
Journal
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