PRMT5 is essential for B cell development and germinal center dynamics
Abstract
Mechanisms regulating B cell development, activation, education in the germinal center (GC) and differentiation, underpin the humoral immune response. Protein arginine methyltransferase 5 (Prmt5), which catalyzes most symmetric dimethyl arginine protein modifications, is overexpressed in B cell lymphomas but its function in normal B cells is poorly defined. Here we show that Prmt5 is necessary for antibody responses and has essential but...
Paper Details
Title
PRMT5 is essential for B cell development and germinal center dynamics
Published Date
Jan 3, 2019
Journal
Volume
10
Issue
1
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