Disassembly of actin and keratin networks by Aurora B kinase at the midplane of cleaving Xenopus laevis eggs

Pages: 513200
Published: Jan 6, 2019
Abstract
null We investigated how bulk cytoplasm prepares for cytokinesis in Xenopus laevis eggs, which are large, rapidly dividing cells. The egg midplane is demarcated by Chromosomal Passenger Complex (CPC) localized on microtubule bundles between asters. Using an extract system and intact eggs we found that local kinase activity of the AURKB subunit of the CPC caused disassembly of F-actin and keratin between asters, and local softening of the...
Paper Details
Title
Disassembly of actin and keratin networks by Aurora B kinase at the midplane of cleaving Xenopus laevis eggs
Published Date
Jan 6, 2019
Journal
Pages
513200
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