Reducing proteolytic liability of a MMP‐14 inhibitory antibody by site‐saturation mutagenesis
Abstract
Playing pivotal roles in tumor growth and metastasis, matrix metalloproteinase-14 (MMP-14) is an important cancer target. Potent inhibitory Fab 3A2 with therapy-desired high selectivity has been isolated from a synthetic antibody library carrying long CDR-H3s. However, like many standard mechanism protease inhibitors, Fab 3A2 can be cleaved by high concentrations of MMP-14 after extended incubation at acidic pH. Edman sequencing of generated 3A2...
Paper Details
Title
Reducing proteolytic liability of a MMP‐14 inhibitory antibody by site‐saturation mutagenesis
Published Date
Jan 11, 2019
Journal
Volume
28
Issue
3
Pages
643 - 653
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