CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repair.

eLife7.70
Volume: 8
Published: Jan 2, 2019
Abstract
CtIP is involved in the resection of broken DNA during the S and G2 phases of the cell cycle for repair by recombination. Acting with the MRN complex, it plays a particularly important role in handling complex DNA end structures by localised nucleolytic processing of DNA termini in preparation for longer range resection. Here we show that human CtIP is a tetrameric protein adopting a dumbbell architecture in which DNA binding domains are...
Paper Details
Title
CtIP forms a tetrameric dumbbell-shaped particle which bridges complex DNA end structures for double-strand break repair.
Published Date
Jan 2, 2019
Journal
Volume
8
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