Reduced nuclear DNA methylation and mitochondrial transcript changes in adenomas do not associate with mtDNA methylation
Abstract
Altered mitochondrial function and large-scale changes to DNA methylation patterns in the nuclear genome are both hallmarks of colorectal cancer (CRC). Mitochondria have multiple copies of a 16 kb circular genome that contains genes that are vital for their function. While DNA methylation is known to alter the nuclear genome in CRC, it is not clear whether it could have a similar influence in mtDNA; indeed, currently, the issue of whether...
Paper Details
Title
Reduced nuclear DNA methylation and mitochondrial transcript changes in adenomas do not associate with mtDNA methylation
Published Date
Dec 1, 2018
Journal
Volume
6
Issue
1
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