Reversal of Aortic Enlargement Induced by Increased Biomechanical Forces Requires AT1R Inhibition in Conjunction With AT2R Activation

Volume: 39, Issue: 3, Pages: 459 - 466
Published: Mar 1, 2019
Abstract
Objective— Pharmacological inhibition of the AT1R (angiotensin II type 1 receptor) with losartan can attenuate ascending aortic remodeling induced by transverse aortic constriction (TAC). In this study, we investigated the role of the AT2R (angiotensin II type 2 receptor) and MasR (Mas receptor) in TAC-induced ascending aortic dilation and remodeling. Approach and Results— Wild-type C57BL/6J mice were subjected to sham or TAC surgeries in the...
Paper Details
Title
Reversal of Aortic Enlargement Induced by Increased Biomechanical Forces Requires AT1R Inhibition in Conjunction With AT2R Activation
Published Date
Mar 1, 2019
Volume
39
Issue
3
Pages
459 - 466
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