Repellent Activity of Carrot Seed Essential Oil and Its Pure Compound, Carotol, Against Mosquitoes

In our natural products screening program for mosquitoes, carrot seed essential oil showed high repellency. The gas chromatography (GC)/flame ionization detector and GC/mass spectrometry analysis of the essential oil revealed the presence of 47 compounds. Carotol was more than 75% w/w, followed by muurolene (4.86%), (Z)-β-farnesene (2.9%), and diepicedrene (1.1%). Systematic bioassay-guided fractionation of the essential oil was performed to...