Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders
Abstract
Resolution of inflammation is an active and dynamic process after surgery. Maresin 1 (MaR1) is one of a growing number of specialised pro-resolving lipids biosynthesised by macrophages that regulates acute inflammation. We investigated the effects of MaR1 on postoperative neuroinflammation, macrophage activity, and cognitive function in mice.Adult male C57BL/6 (n=111) and Ccr2RFP/+Cx3cr1GFP/+ (n=54) mice were treated with MaR1 before undergoing...
Paper Details
Title
Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders
Published Date
Mar 1, 2019
Volume
122
Issue
3
Pages
350 - 360
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