Helix–loop–helix proteins and the advent of cellular diversity: 30 years of discovery
Abstract
Helix-loop-helix (HLH) proteins are dimeric transcription factors that control lineage- and developmental-specific gene programs. Genes encoding for HLH proteins arose in unicellular organisms >600 million years ago and then duplicated and diversified from ancestral genes across the metazoan and plant kingdoms to establish multicellularity. Hundreds of HLH proteins have been identified with diverse functions in a wide variety of cell types. HLH...
Paper Details
Title
Helix–loop–helix proteins and the advent of cellular diversity: 30 years of discovery
Published Date
Jan 1, 2019
Journal
Volume
33
Issue
1-2
Pages
6 - 25
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