Effect of the SIRT1 gene on regional cortical grey matter density in the Han Chinese population

Published on Dec 20, 2018in British Journal of Psychiatry7.233
· DOI :10.1192/bjp.2018.270
Shuquan Rao2
Estimated H-index: 2
Na Luo2
Estimated H-index: 2
+ 2 AuthorsFuquan Zhang8
Estimated H-index: 8
  • References (30)
  • Citations (1)
#1Hong Chang (KIZ: Kunming Institute of Zoology)H-Index: 8
#2Naosuke Hoshina (OIST: Okinawa Institute of Science and Technology)H-Index: 6
Last. Ming Li (KIZ: Kunming Institute of Zoology)H-Index: 22
view all 36 authors...
Major mood disorders, which primarily include bipolar disorder and major depressive disorder, are the leading cause of disability worldwide and pose a major challenge in identifying robust risk genes. Here, we present data from independent large-scale clinical data sets (including 29 557 cases and 32 056 controls) revealing brain expressed protocadherin 17 (PCDH17) as a susceptibility gene for major mood disorders. Single-nucleotide polymorphisms (SNPs) spanning the PCDH17 region are significant...
27 CitationsSource
#1Elizabeth LippardH-Index: 6
#2Kevin P. Jensen (Yale University)H-Index: 17
Last. Hilary P. Blumberg (Yale University)H-Index: 39
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The single-nucleotide polymorphism rs9804190 in the Ankyrin G (ANK3) gene has been reported in genome-wide association studies to be associated with bipolar disorder (BD). However, the neural system effects of rs9804190 in BD are not known. We investigated associations between rs9804190 and gray and white matter (GM and WM, respectively) structure within a frontotemporal neural system implicated in BD. A total of 187 adolescent and adult European Americans were studied: a group homozygous for th...
10 CitationsSource
#1Lianne Schmaal (VUmc: VU University Medical Center)H-Index: 22
#2Derrek P. Hibar (SC: University of Southern California)H-Index: 37
Last. Dick J. Veltman (VUmc: VU University Medical Center)H-Index: 69
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The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with ha...
186 CitationsSource
#1Naoko Abe-Higuchi (Yamaguchi University)H-Index: 3
#2Shusaku Uchida (Yamaguchi University)H-Index: 17
Last. Yoshifumi Watanabe (Yamaguchi University)H-Index: 25
view all 8 authors...
Abstract Background Although depression is the leading cause of disability worldwide, its pathophysiology is poorly understood. Recent evidence has suggested that sirtuins (SIRTs) play a key role in cognition and synaptic plasticity, yet their role in mood regulation remains controversial. Here, we aimed to investigate whether SIRT function is associated with chronic stress-elicited depression-like behaviors and neuronal atrophy. Methods We measured SIRT expression and activity in a mouse model ...
52 CitationsSource
14 CitationsSource
#1Craig L. HydeH-Index: 20
#2Michael W. NagleH-Index: 8
Last. Ashley R. WinslowH-Index: 17
view all 10 authors...
Ashley Winslow, Roy Perlis, David Hinds and colleagues report the identification of 15 genetic loci associated with risk of major depressive disorder in individuals of European descent. They find that several loci are also associated with risk of other psychiatric traits, including schizophrenia and neuroticism.
268 CitationsSource
#1Hee Dae Kim (UA: University of Arizona)H-Index: 2
#2Jennifer Hesterman (UA: University of Arizona)H-Index: 1
Last. Deveroux Ferguson (UA: University of Arizona)H-Index: 30
view all 10 authors...
Depression is a recurring and life-threatening illness that affects up to 120 million people worldwide. In the present study, we show that chronic social defeat stress, an ethologically validated model of depression in mice, increases SIRT1 levels in the nucleus accumbens (NAc), a key brain reward region. Increases in SIRT1, a well characterized class III histone deacetylase, after chronic social defeat suggest a role for this enzyme in mediating depression-like behaviors. When resveratrol, a ph...
40 CitationsSource
#1Lianne Schmaal (VUmc: VU University Medical Center)H-Index: 22
#2Dick J. Veltman (VUmc: VU University Medical Center)H-Index: 69
Last. Derrek P. Hibar (SC: University of Southern California)H-Index: 37
view all 62 authors...
The pattern of structural brain alterations associated with major depressive disorder (MDD) remains unresolved. This is in part due to small sample sizes of neuroimaging studies resulting in limited statistical power, disease heterogeneity and the complex interactions between clinical characteristics and brain morphology. To address this, we meta-analyzed three-dimensional brain magnetic resonance imaging data from 1728 MDD patients and 7199 controls from 15 research samples worldwide, to identi...
316 CitationsSource
#1Jing Sui (CAS: Chinese Academy of Sciences)H-Index: 31
#2Godfrey D. Pearlson (Yale University)H-Index: 110
Last. Vince D. CalhounH-Index: 93
view all 9 authors...
BACKGROUND: The cognitive deficits of schizophrenia are largely resistant to current treatments and thus are a lifelong illness burden. The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) provides a reliable and valid assessment of cognition across major cognitive domains; however, the multimodal brain alterations specifically associated with MCCB in schizophrenia have not been examined.
67 CitationsSource
#1Derrek P. Hibar (SC: University of Southern California)H-Index: 37
#2Janet L. Stein (SC: University of Southern California)H-Index: 96
Last. Sarah E. Medland (Heidelberg University)H-Index: 77
view all 287 authors...
The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magneti...
443 CitationsSource
Cited By1
#1W. Liu (KIZ: Kunming Institute of Zoology)H-Index: 3
#2Hao Yan (PKU: Peking University)H-Index: 13
Last. Xiao Xiao (KIZ: Kunming Institute of Zoology)H-Index: 10
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Major depressive disorder (MDD) is recognized as a primary cause of disability worldwide, and effective management of this illness has been a great challenge. While genetic component is supposed to play pivotal roles in MDD pathogenesis, the genetic and phenotypic heterogeneity of the illness has hampered the discovery of its genetic determinants. In this study, in an independent Han Chinese sample (1824 MDD cases and 3031 controls), we conducted replication analyses of two genetic loci highligh...
2 CitationsSource
#1Takashi Hirata (Kobe University)H-Index: 1
#2Ikuo Otsuka (Kobe University)H-Index: 4
Last. Akitoyo Hishimoto (Kobe University)H-Index: 15
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Abstract A recent genome-wide association study (GWAS) for major depressive disorder (MDD) in Chinese women identified a single-nucleotide polymorphism (SNP), rs12415800, near the Sirtuin1 (SIRT1) gene as one of the top candidate loci. However, no study has shown a genetic association between SIRT1 and completed suicide, which is one of the most serious outcomes of MDD. In this study, 778 suicide completers and 760 controls in a Japanese population were genotyped for two SNPs in strong linkage d...