Effect of the SIRT1 gene on regional cortical grey matter density in the Han Chinese population

Background Our previous genome-wide association study (CONVERGE sample) identified significant association between single nucleotide polymorphisms (SNPs) near the SIRT1 gene and major depressive disorder (MDD) in Chinese populations. Aims To investigate whether SNPs across the SIRT1 gene locus affect regional grey matter density in the Han Chinese population. Method T1-weighted structural magnetic resonance imaging was conducted on 92 healthy...