Cytotoxicity of liposome-encapsulated polyinosinic-polycytidylic acid in primary human macrophages is only partially related to interferon-ß
Published: Sep 15, 2018
Abstract
Background: We demonstrated (ERJ 2017;50 Suppl. 61:PA2030) that polyinosinic-polycytidylic acid (poly(I:C)) encapsulated within novel cationic pH-sensitive liposomes stimulates a potent interferon (IFN)-β response in primary human monocyte-derived macrophages (MDM). IFN-β response, useful for antiviral defence, often raises concerns of cytotoxicity. Aim: To examine potential cytotoxicity of liposome-encapsulated poly(I:C) in MDM....
Paper Details
Title
Cytotoxicity of liposome-encapsulated polyinosinic-polycytidylic acid in primary human macrophages is only partially related to interferon-ß
Published Date
Sep 15, 2018
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