Design and analysis considerations for combining data from multiple biomarker studies
Abstract
Pooling data from multiple studies improves estimation of exposure‐disease associations through increased sample size. However, biomarker exposure measurements can vary substantially across laboratories and often require calibration to a reference assay prior to pooling. We develop two statistical methods for aggregating biomarker data from multiple studies: the full calibration method and the internalized method. The full calibration method...
Paper Details
Title
Design and analysis considerations for combining data from multiple biomarker studies
Published Date
Dec 19, 2018
Journal
Volume
38
Issue
8
Pages
1303 - 1320
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