Antithrombin Insufficiency Promotes Susceptibility to Liver Tumorigenesis

Background Antithrombin (AT) is not only a major regulator of hemostasis, but it shows anti-inflammatory properties as well. We aimed to investigate whether AT-insufficient mice increase susceptibility to liver tumorigenesis. Methods We induced the development of liver tumor in AT-insufficient (AT+/−) mice and wild-type (AT+/+) mice by treating them with diethylnitrosamine (DEN) and CCl4. The development of liver tumors and liver inflammation...