PCN377 - RESPONSE SHIFT EFFECT ON QUALITY OF LIFE IN RANDOMIZED CONTROL TRIAL OF TAXANE VERSUS S-1 FOR METASTATIC BREAST CANCER PATIENTS (SELECT-BC): STRUCTURAL EQUATION MODELING

We investigated quantification of the response shift effect on observed quality of life (QOL) data in the randomized control trial of taxane versus S-1 for metastatic breast cancer patients (SELECT-BC). The response shift effect on observed QOL data measured by EORTC QLQ-C30 in SELECT-BC were analyzed using structural equation modeling technique and the ‘true’ effect of the treatments were quantified. The results of the analysis were presented...