KCNK3 channel inactivation leads to pulmonary vascular alterations in rat

Introduction: Mutations in the KCNK3 gene, which encodes for an outward rectifier K+ channel, have been identified in Pulmonary Arterial Hypertension (PAH) patients. Each identified mutations leads to a loss of KCNK3 function. Aims and Objectives: KCNK3 is not functional in mouse PASMCs, to decipher cellular mechanisms associated with a loss of KCNK3 function in PAH, we generated a transgenic rat line. Methods: Using...