Exploration of organotin(IV) derivatives for medicinal applications: Synthesis, spectroscopic characterization, structural elucidation and molecular docking study

Published on Apr 1, 2019in Journal of Molecular Structure2.12
· DOI :10.1016/j.molstruc.2018.12.041
Muhammad Sirajuddin13
Estimated H-index: 13
(University of Science and Technology),
Saqib Ali29
Estimated H-index: 29
(QAU: Quaid-i-Azam University)
+ 2 AuthorsMehreen Ghufran6
Estimated H-index: 6
(AWKUM: Abdul Wali Khan University Mardan)
Abstract Organotin (IV) derivatives of carboxylate ligand, 4-(4-methoxyanilino)-4-oxobutanoic acid, have been synthesized and characterized by FTIR, NMR, CHN analysis, mass spectrometry and X-ray crystallography. Single crystal data of four compounds ( 1–4 ) displayed a distorted trigonal bipyramidal environment around Sn with the three equatorial positions occupied by alkyl group. In compounds 1–3 , carboxylate oxygens of ligand play the role of a bridge between the adjacent tin atoms symmetrically giving a polymeric chain structure. In compound 4 , oxygen of the amide carbonyl moiety perform the same function and bridges the adjacent tin atoms [Sn O = 2.155 (3) and 2.428 (3) A, respectively], with the three phenyl ipso -C atoms defining the trigonal plane and the axial positions occupied by O atoms [O1 Sn O3 = 177.62 (11) A]. The τ values calculated for complexes 1–4 are 0.78, 0.77, 0.82 and 0.92, respectively, also confirm the trigonal bipyramidal geometry. The antimicrobial results of the synthesized compounds illustrate their use as a potential antimicrobial agent. The DNA interaction study performed by UV–visible spectroscopy as well as by molecular docking suggests the tested compounds interact with DNA through intercalation mode. The compounds were screened for anticancer activity performed against lung carcinoma and Vero cell lines resulting in activity that is almost equivalent to that of the standard, vincristine. The biological significance of these compounds is that there affect on the normal cell line is very small i.e.,
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  • Citations (2)
#1Muhammad Sirajuddin (CUI: COMSATS Institute of Information Technology)H-Index: 2
#2Saqib Ali (QAU: Quaid-i-Azam University)H-Index: 29
Last.Jamshad Iqbal (CUI: COMSATS Institute of Information Technology)H-Index: 2
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Cited By2
#1Badri Z. Momeni (KNTU: K.N.Toosi University of Technology)H-Index: 9
#2Nastaran Fathi (KNTU: K.N.Toosi University of Technology)H-Index: 2
Last.Jan Janczak (PAN: Polish Academy of Sciences)H-Index: 26
view all 4 authors...
View next paperSpectroscopic characterizations, structural peculiarities, molecular docking study and evaluation of biological potential of newly designed organotin(IV) carboxylates