Tuning recombinant protein expression to match secretion capacity
Abstract
The secretion of recombinant disulfide-bond containing proteins into the periplasm of Gram-negative bacterial hosts, such as E. coli, has many advantages that can facilitate product isolation, quality and activity. However, the secretion machinery of E. coli has a limited capacity and can become overloaded, leading to cytoplasmic retention of product; which can negatively impact cell viability and biomass accumulation. Fine control over...
Paper Details
Title
Tuning recombinant protein expression to match secretion capacity
Published Date
Dec 1, 2018
Journal
Volume
17
Issue
1
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