Alternative oxidase‐mediated respiration prevents lethal mitochondrial cardiomyopathy
Abstract
Alternative oxidase (AOX) is a non-mammalian enzyme that can bypass blockade of the complex III-IV segment of the respiratory chain (RC). We crossed a Ciona intestinalis AOX transgene into RC complex III (cIII)-deficient Bcs1lp.S78G knock-in mice, displaying multiple visceral manifestations and premature death. The homozygotes expressing AOX were viable, and their median survival was extended from 210 to 590 days due to permanent prevention of...
Paper Details
Title
Alternative oxidase‐mediated respiration prevents lethal mitochondrial cardiomyopathy
Published Date
Dec 10, 2018
Journal
Volume
11
Issue
1
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