Zwitterionic functionalised mesoporous silica nanoparticles for alendronate release
Abstract
Novel zwitterionic surface modified mesoporous silica nanoparticles (MSNs) were prepared for alendronate release. Phospholipid moieties were generated by the ring-opening reaction of 2-chloro-2-oxo-1,3,2-dioxaphospholane (COP) subsequent to (3-bromopropyl) trimethoxysilane immobilisation. Studies confirmed the successful introduction of phosphorylcholine (PC) groups at the surface without sacrificing the original structure of MCM41. The...
Paper Details
Title
Zwitterionic functionalised mesoporous silica nanoparticles for alendronate release
Published Date
May 1, 2019
Volume
279
Pages
117 - 127
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