Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation

Volume: 18, Issue: 1
Published: Dec 10, 2018
Abstract
Metazoans viability depends on their ability to regulate metabolic processes and also to respond to harmful challenges by mounting anti-stress responses; these adaptations were fundamental forces during evolution. Central to anti-stress responses are a number of short-lived transcription factors that by functioning as stress sensors mobilize genomic responses aiming to eliminate stressors. We show here that increased expression of nuclear factor...
Paper Details
Title
Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation
Published Date
Dec 10, 2018
Journal
Volume
18
Issue
1
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