Increased Fibro-Adipogenic Progenitors and Intramyocellular Lipid Accumulation in Obesity-Related Skeletal Muscle Dysfunction

The obesity epidemic is one of the most serious public health problems in the world. Today, about two out of three adults (69%) are overweight or obese in the U.S. In healthy persons, peripheral subcutaneous fat tissue makes up 80% of total body fat (1), and another 10% of adipose tissue is present as either abdominal visceral fat tissue or that in and around organs, including the vasculature, heart, and skeletal muscle (2). Skeletal muscle is...