Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer
Abstract
•PKCδ is a common mediator shared by multiple TKI-resistant pathways•TKI-induced EGFR heterodimers promote nuclear PKCδ and TKI resistance•Nuclear PKCδ associates with worse TKI response in EGFR-mutant NSCLC patients•Inhibition of PKCδ sensitizes resistant EGFR-mutant NSCLC to EGFR TKI Multiple mechanisms of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been identified in EGFR-mutant non-small cell...
Paper Details
Title
Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer
Published Date
Dec 1, 2018
Journal
Volume
34
Issue
6
Pages
954 - 969.e4
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Notes
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