Synthesis and Anti‐proliferative Activity of Novel Polysubstitued Indazole Derivatives

A simple and efficient process is developed for the synthesis of new N ‐(1‐alkyl‐3‐chloro‐4‐ethoxy‐1 H ‐indazol‐5‐yl)‐arylsulfonamides 4a – d and N ‐(1‐alkyl‐3‐chloro‐1 H ‐indazol‐5‐yl)‐arylsulfonamides 5a – d through the reduction of 1‐alkyl‐3‐chloro‐5‐nitroindazoles 2a , b with SnCl 2 in ethanol followed by coupling the corresponding amine with arylsulfonyl chlorides in pyridine. All the newly synthesized compounds have been characterized by...