Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging
Abstract
A hallmark of adult hematopoiesis is the continuous replacement of blood cells with limited lifespans. While active hematopoietic stem cell (HSC) contribution to multilineage hematopoiesis is the foundation of clinical HSC transplantation, recent reports have questioned the physiological contribution of HSCs to normal/steady-state adult hematopoiesis. Here, we use inducible lineage tracing from genetically marked adult HSCs and reveal robust...
Paper Details
Title
Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging
Published Date
Dec 18, 2018
Journal
Volume
7
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