High-resolution deconstruction of evolution induced by chemotherapy treatments in breast cancer xenografts
Abstract
The processes by which tumors evolve are essential to the efficacy of treatment, but quantitative understanding of intratumoral dynamics has been limited. Although intratumoral heterogeneity is common, quantification of evolution is difficult from clinical samples because treatment replicates cannot be performed and because matched serial samples are infrequently available. To circumvent these problems we derived and assayed large sets of human...
Paper Details
Title
High-resolution deconstruction of evolution induced by chemotherapy treatments in breast cancer xenografts
Published Date
Dec 18, 2018
Journal
Volume
8
Issue
1
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