Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot, and reduce bleeding complications

Blood20.30
Volume: 133, Issue: 11, Pages: 1233 - 1244
Published: Mar 14, 2019
Abstract
Bleeding complications secondary to surgery, trauma, or coagulation disorders are important causes of morbidity and mortality. Although fibrin sealants are considered to minimize blood loss, this is not widely adopted because of its high cost and/or risk for infection. We present a novel methodology employing nonantibody fibrinogen-binding proteins, termed Affimers, to stabilize fibrin networks with the potential to control excessive bleeding....
Paper Details
Title
Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot, and reduce bleeding complications
Published Date
Mar 14, 2019
Journal
Volume
133
Issue
11
Pages
1233 - 1244
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