Protection of tissue physicochemical properties using polyfunctional crosslinkers
Abstract
Controlled tissue fixation with polyepoxides protects protein fluorescence, antigenicity, nucleic acids and tissue architecture. Understanding complex biological systems requires the system-wide characterization of both molecular and cellular features. Existing methods for spatial mapping of biomolecules in intact tissues suffer from information loss caused by degradation and tissue damage. We report a tissue transformation strategy named...
Paper Details
Title
Protection of tissue physicochemical properties using polyfunctional crosslinkers
Published Date
Dec 17, 2018
Journal
Volume
37
Issue
1
Pages
73 - 83
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Notes
History