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Preparation of pH-responsive avermectin/feather keratin-hyaluronic acid with anti-UV and sustained-release properties

Published on Mar 1, 2019in Colloids and Surfaces B: Biointerfaces3.97
· DOI :10.1016/j.colsurfb.2018.11.074
Guanquan Lin2
Estimated H-index: 2
(Zhongkai University of Agriculture and Engineering),
Hongjun Zhou3
Estimated H-index: 3
+ 3 AuthorsXinhua Zhou4
Estimated H-index: 4
(Zhongkai University of Agriculture and Engineering)
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Abstract
Abstract In an effort to improve the utilization of pesticides, an environmentally friendly carrier material was prepared to encapsulate pesticides and to prevent pesticides from decomposing under natural conditions with sustained-release effect. The carrier of feather keratin-hyaluronic acid (FK-HA) was prepared by Maillard reaction. Using avermectin (AVM) as a model drug, AVM/FK-HA was obtained by heating. Its structure and morphology were measured by SDS-PAGE, Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermal gravimetric analyzer (TGA) and dynamic light scattering (DLS). Furthermore, the encapsulation efficiency, anti-UV, sustained-release and toxicological properties were investigated. The results showed that AVM/FK-HA featured an average particle size of 473.82 nm, with nearly spherical shape. Furthermore, the material exhibited a high surface charge and was capable of homogeneous dispersion. The encapsulation efficiency was found to be as high as 81.25%. Compared to pure AVM, the pesticide encapsulated by FK-HA (i.e. AVM/FK-HA) could reduce drug decomposition by 20% after ultraviolet irradiation for 52 h. Moreover, mass ratio, temperature and varying pH values exhibited an effect on the sustained release of the drug and the release mechanism was consistent with Fick diffusion. Finally, the difference between the toxicological effects of AVM encapsulated by FK-HA and pure AVM were not significant.
  • References (50)
  • Citations (2)
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References50
Newest
Published on Jul 1, 2018in Journal of Polymers and The Environment2.77
Huayao Chen3
Estimated H-index: 3
(Zhongkai University of Agriculture and Engineering),
Guanquan Lin2
Estimated H-index: 2
(Zhongkai University of Agriculture and Engineering)
+ 3 AuthorsSuqing Huang1
Estimated H-index: 1
(Zhongkai University of Agriculture and Engineering)
Avermectin (AVM) is a highly efficient pesticide against a variety of insects and is widely used in agriculture. However, it is susceptible to oxidation and photolysis, resulting in instability under UV irradiation and a short half-life. Herein, sodium carboxymethyl cellulose (CMC) was grafted by styrene (St), Methyl methacrylate (MMA) and butyl acrylate (BA) respectively to prepare grafted polymer nanoparticles in application for AVM sustained released. And the influence of different grafted mo...
Published on May 9, 2018in Nanomaterials4.03
Zhichuan Shen1
Estimated H-index: 1
,
Hongjun Zhou3
Estimated H-index: 3
+ 3 AuthorsXinhua Zhou4
Estimated H-index: 4
Salicylaldimine-modified mesoporous silica (Sal-MCM-3 and Sal-MCM-9) was prepared through a co-condensation method with different amounts of added salicylaldimine. With the coordination from the salicylaldimine, zinc ions were impregnated on Sal-MCM-3 and Sal-MCM-9. Then, Zn-Sal-MCM-3 and Zn-Sal-MCM-9 were calcined to obtain nano-zinc oxide loaded on mesoporous silica (ZnO-MCM-3 and ZnO-MCM-9). The material structures were systematically studied by Fourier transform infrared spectroscopy (FTIR),...
Published on May 1, 2018in Materials2.97
Guanquan Lin2
Estimated H-index: 2
,
Huayao Chen3
Estimated H-index: 3
+ 2 AuthorsHua Xu3
Estimated H-index: 3
Using butyl methacrylate (BMA) and styrene (St) as monomers and divinylbenzene (DVB) as a crosslinking agent, P(St-BMA) microspheres were prepared by suspension polymerization. Tea tree oil (TTO) microspheres were prepared by adsorbing TTO on P(St-BMA) microspheres. The structure and surface morphology of P(St-BMA) microspheres and TTO microspheres were characterized by Fourier transformed infrared spectroscopy (FTIR), optical microscopy, and Thermogravimetric analysis (TGA). In doing so, the st...
Published on May 1, 2018in Colloids and Surfaces B: Biointerfaces3.97
Cihui Tian3
Estimated H-index: 3
(CPU: China Pharmaceutical University),
Sajid Asghar9
Estimated H-index: 9
(GCUF: Government College University, Faisalabad)
+ 6 AuthorsYanyu Xiao15
Estimated H-index: 15
(CPU: China Pharmaceutical University)
Abstract In this study, a redox-sensitive glioma-targeting micelle system was designed to deliver curcumin (CUR) by conjugating it to hyaluronic acid (HA-s-s-CUR, HSC) via disulfide linkage. The effect of the molecular weight of HA on the physicochemical characteristics of HSC conjugates and their in vitro effects in glioma cells were also explored. These conjugates formed nano-scale micelles (209–926 nm) independently in aqueous solution. The micelles greatly increased the solubility of CUR and...
Published on Mar 21, 2018in Journal of Agricultural and Food Chemistry3.57
Yujia Tong3
Estimated H-index: 3
(CAU: China Agricultural University),
Leihou Shao1
Estimated H-index: 1
(Center for Excellence in Education)
+ 6 AuthorsXuemin Wu4
Estimated H-index: 4
(CAU: China Agricultural University)
Pesticide carrier systems are highly desirable in achieving the effective utilization of pesticides and reduction of their loss. In order to increase utilization and enhance pesticide adhesion to harmful targets, adhesive and stimulus-responsive nanocomposites were prepared using graphene oxide (GO) and polydopamine (PDA). The results demonstrated that graphene oxide with a layer of PDA had a high hymexazol-loading capacity. The release curve of hymexazol from the nanocomposite showed that the r...
Published on Mar 1, 2018in Carbohydrate Polymers6.04
Yacheng Hao1
Estimated H-index: 1
(SCUT: South China University of Technology),
Yun Chen1
Estimated H-index: 1
(SCUT: South China University of Technology)
+ 1 AuthorsQunyu Gao13
Estimated H-index: 13
(SCUT: South China University of Technology)
Abstract A comparative experiment about the production of starch nanocrystals (SNCs) with/without glucoamylase enzymatic pretreatment by sulfate acid hydrolysis from waxy potato starch (WPS) was employed in the present study. The research focused on the enhancement of the preparation efficiency while improving the dispersion of SNCs at the same time. The enzymatic pretreatment resulted in the decrease of acid hydrolysis duration. The minimum size and best dispersibility of nanocrystals was obtai...
Published on Feb 14, 2018in Journal of Agricultural and Food Chemistry3.57
Jhones Luiz de Oliveira6
Estimated H-index: 6
(UNESP: Sao Paulo State University),
Estefania Vangelie Ramos Campos3
Estimated H-index: 3
(State University of Campinas)
+ 6 AuthorsLeonardo Fernandes Fraceto31
Estimated H-index: 31
(State University of Campinas)
Botanical repellents represent one of the main ways of reducing the use of synthetic pesticides and the contamination of soil and hydric resources. However, the poor stability and rapid degradation of these compounds in the environment hinder their effective application in the field. Zein nanoparticles can be used as eco-friendly carrier systems to protect these substances against premature degradation, provide desirable release characteristics, and reduce toxicity in the environment and to huma...
Published on Feb 11, 2018in Nanomaterials4.03
Bingna Huang1
Estimated H-index: 1
,
Feifei Chen1
Estimated H-index: 1
+ 8 AuthorsFei Gao3
Estimated H-index: 3
Pesticides are the basis for defending against major biological disasters and important for ensuring national food security. Biocompatible, biodegradable, intelligent, and responsive materials are currently an emerging area of interest in the field of efficient, safe, and green pesticide formulation. Using nanotechnology to design and prepare targeted pesticides with environmentally responsive controlled release via compound and chemical modifications has also shown great potential in creating n...
Published on Feb 1, 2018in Molecular Biology and Evolution14.80
Ping Wu23
Estimated H-index: 23
(SC: University of Southern California),
Jie Yan3
Estimated H-index: 3
(SC: University of Southern California)
+ 8 AuthorsWen-Hsiung Li94
Estimated H-index: 94
(AS: Academia Sinica)
Published on Feb 1, 2018in Clinical Pharmacokinectics4.68
Rajith Kumar Reddy Rajoli5
Estimated H-index: 5
(University of Liverpool),
David Back65
Estimated H-index: 65
(University of Liverpool)
+ 4 AuthorsMarco Siccardi28
Estimated H-index: 28
(University of Liverpool)
Background and Objectives Long-acting injectable antiretrovirals represent a pharmacological alternative to oral formulations and an innovative clinical option to address adherence and reduce drug costs. Clinical studies in children and adolescents are characterised by ethical and logistic barriers complicating the identification of dose optimisation. Physiologically-based pharmacokinetic modelling represents a valuable tool to inform dose finding prior to clinical trials. The objective of this ...
Cited By2
Newest
Published on Jun 28, 2019in Environmental Science and Pollution Research2.91
Guanghua Liu (Zhongkai University of Agriculture and Engineering), Guanquan Lin2
Estimated H-index: 2
(Zhongkai University of Agriculture and Engineering)
+ 4 AuthorsXinhua Zhou4
Estimated H-index: 4
(Zhongkai University of Agriculture and Engineering)
The overdosage use of pesticide was harmful to the environment and human health, which was mainly caused by the low utilization rate of the pesticide. However, the pesticide microcapsule with sustained-release and stimulating response properties could effectively solve this problem. Preparation of carboxymethyl cellulose grafting dimethyldiallylammonium chloride (CMC-g-PDMDAAC) through grafting polymerization and trapping as well as encapsulation of avermectin (AVM) via electrostatic interaction...
Published on Jul 26, 2019in Royal Society Open Science2.52
Long Chen (Zhongkai University of Agriculture and Engineering), Hongjun Zhou3
Estimated H-index: 3
(Zhongkai University of Agriculture and Engineering)
+ 2 AuthorsXinhua Zhou4
Estimated H-index: 4
(Zhongkai University of Agriculture and Engineering)
Carboxymethyl cellulose (CMC) was grafted onto the surface of soy protein isolate (SPI) to obtain soy protein isolate-carboxymethyl cellulose conjugate (SPC). Avermectin (AVM) was hydrophobically e...
Published on Jul 9, 2019in Polymer Journal2.64
Guanghua Liu (Zhongkai University of Agriculture and Engineering), Guanquan Lin2
Estimated H-index: 2
(Zhongkai University of Agriculture and Engineering)
+ 4 AuthorsXinhua Zhou4
Estimated H-index: 4
(Zhongkai University of Agriculture and Engineering)
To improve the utilization of pesticides and reduce the amount of pesticides used, sustained-release nanoparticles were prepared. Soybean protein isolate (SPI) and carboxymethyl cellulose (CMC) were modified to obtain hydrazine-modified SPI and aldehyde-modified CMC, respectively, and SPI-CMC was prepared by the condensation of hydrazine and aldehyde groups, forming a hydrazone bond. SPI-CMC was heated and loaded with avermectin (AVM) to obtain AVM/SPI-CMC. The encapsulation efficiency property,...