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Differences in the actions of adrenaline and noradrenaline with regard to glucose intolerance in patients with pheochromocytoma.

Published on Jan 1, 2019in Endocrine Journal1.94
路 DOI :10.1507/endocrj.EJ18-0407
Ichiro Abe5
Estimated H-index: 5
(Fukuoka University),
Hideyuki Fujii1
Estimated H-index: 1
(Fukuoka University)
+ 9 AuthorsKunihisa Kobayashi33
Estimated H-index: 33
(Fukuoka University)
Abstract
  • References (18)
  • Citations (1)
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References18
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#1Ichiro Abe (Fukuoka University)H-Index: 5
#2Kaoru Sugimoto (Fukuoka University)H-Index: 1
Last. Kunihisa Kobayashi (Fukuoka University)H-Index: 33
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#1Hisako Komada (Kobe University)H-Index: 7
#2Yushi Hirota (Kobe University)H-Index: 18
Last. Wataru Ogawa (Kobe University)H-Index: 5
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#1Stephen Rattigan (Menzies Research Institute)H-Index: 36
#2Stephen M. Richards (Menzies Research Institute)H-Index: 22
Last. Michelle A. Keske (Menzies Research Institute)H-Index: 12
view all 3 authors...
The notion that type 2 diabetes and insulin resistance are associated with many macro- and microvascular defects (1,2) is unquestionable, but whether vascular defects precede and contribute to insulin resistance is less certain and has been a controversial topic. The most compelling evidence for a vascular involvement in insulin resistance has been in skeletal muscle (3), but recent research has also implicated its involvement in adipose tissue (4), which may then lead to whole body insulin resi...
13 CitationsSource
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#1Barry R. JohnsH-Index: 2
#2Fahim AbbasiH-Index: 47
Last. Gerald M. ReavenH-Index: 117
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BACKGROUND: Several surrogate estimates have been used to define relationships between insulin action and pancreatic 尾-cell function in healthy individuals. Because it is unclear how conclusions about insulin secretory function depend on specific estimates used, we evaluated the effect of different approaches to measurement of insulin action and secretion on observations of pancreatic 尾-cell function in individuals whose fasting plasma glucose (FPG) was <7.0 mmol/L (126 mg/dL). METHODS: We deter...
5 CitationsSource
#1Nicole ReischH-Index: 18
Last. Hartmut P. H. NeumannH-Index: 59
view all 4 authors...
Pheochromocytomas are rare, mostly benign catecholamine-producing tumors of chromaffin cells of the adrenal medulla or of a paraganglion. Typical clinical manifestations are sustained or paroxysmal hypertension, severe headaches, palpitations and sweating resulting from hormone excess. However, thei
138 CitationsSource
#1Andrea Sieg (University of Cologne)H-Index: 2
#2Jiping Su (University of Cologne)H-Index: 4
Last. Susanne UllrichH-Index: 10
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This study examines the effect of epinephrine, a known physiological inhibitor of insulin secretion, on the membrane potential of pancreatic islet cells from sulfonylurea receptor-1 (ABCC8)-null mice (Sur1KO), which lack functional ATP-sensitive K+ (KATP) channels. These channels have been argued to be activated by catecholamines, but epinephrine effectively inhibits insulin secretion in both Sur1KO and wild-type islets and in mice. Isolated Sur1KO 尾-cells are depolarized in both low (2.8 mmol/l...
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#1Tobias Wiesner (Leipzig University)H-Index: 6
#2Matthias Bl眉her (Leipzig University)H-Index: 79
Last. Ralf Paschke (Leipzig University)H-Index: 59
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Objective: Decreased insulin secretion is considered to be the main cause for pheochromocytoma-associated diabetes mellitus. Data from animal and evidence from clinical studies suggest that catecholamines can induce insulin resistance. However, there is no study investigating the effect of catecholamine excess on insulin resistance in patients with pheochromocytopma by the euglycemic hyperinsulinaemic clamp technique. Research Design and Methods: We characterized the effect of high catecholamine...
79 CitationsSource
#1Matthias Bl眉her (Leipzig University)H-Index: 79
#2M. Windgassen (Leipzig University)H-Index: 2
Last. Ralf Paschke (Leipzig University)H-Index: 59
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30 CitationsSource
#2Harry R. Keiser (NIH: National Institutes of Health)H-Index: 62
Last. W. M. LinehanH-Index: 123
view all 3 authors...
Pheochromocytoma is a catecholamine-producing tumor of the sympathetic nervous system. Signs and symptoms are generally related to catecholamine excess; these include hypertension, sweating, palpitatione, headaches, and anxiety attacks. Abdominal imaging and 24-h urine collection for catecholamines are usually be sufficient for diagnosis. Catecholamine blockade with phenoxybenzamine and metyrosine generally ameliorates symptoms and is necessary to prevent hypertensive crisis during surgery. Stan...
113 CitationsSource
Cited By1
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#1Masaya MurabayashiH-Index: 1
#2Makoto DaimonH-Index: 33
Last. Ken TeruiH-Index: 10
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Source
#1Martin B. Niederle (University of Vienna)
Die Behandlung von Katecholamin-produzierenden Tumoren (Phaochromozytom, Paragangliom [PPGL]) ist eine Herausforderung fur das gesamte perioperative Betreuungsteam bestehend aus Endokrinologie, Anasthesie und Chirurgie. Hamodynamische und metabolische Extremereignisse sind haufig und konnen zu kardialen und zerebrovaskularen Komplikationen fuhren. Die Morbiditat und Mortalitat in der chirurgischen Therapie ist aber durch moderne Behandlungskonzepte gering geworden. Die bisher als Dogma angesehen...
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