Abstract 097: Interaction of miRNA, Endothelial Mineralocorticoid Receptor and Epithelial Sodium Channel in Endothelium Stiffness and Aortic Dysfunction

Excessive endothelial cell (EC) mineralocorticoid receptor (ECMR) and epithelial sodium channel activation in endothelium (EnNaC) increase oxidative stress and inflammation with associated cardiovascular abnormalities. Previous studies implicate elevations in circulating aldosterone (Aldo) in obesity enhance ECMR/EnNaC signaling that contribute to the development of vascular stiffness, in part, by reducing endothelial nitric oxide (NO) synthase...