Role of HHV-6 subtypes in accelerating EAE progression

We enthusiastically read the article in PNAS by Leibovitch et al. (1), in which they show that intranasal inoculations with human herpesvirus (HHV)-6A and HHV-6B accelerate the onset and severity of experimental autoimmune encephalomyelitis (EAE). They performed an outstanding job in utilizing marmosets to mimic the multiple sclerosis (MS)-like symptoms rather than female C57BL/6 mice. Although the creativity of their work is undeniable, several...