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Published on Jan 1, 2017in Neuroscience & Biobehavioral Reviews 8.04
Jessica B. Myles1
Estimated H-index: 1
(Monash University),
Susan L. Rossell31
Estimated H-index: 31
(Monash University)
+ 2 AuthorsCaroline Gurvich16
Estimated H-index: 16
(Monash University)
Abstract Myles, J.B., S. Rossell, A. Phillipou, Thomas, E and C. Gurvich. A systematic review of saccadic eye movements across the schizophrenia continuum: Characterisation, pathophysiology and genetic associations. NEUROSCI BIOBEHAV REV 21(1) XXX–XXX, 2015. One of the cognitive hallmarks of schizophrenia is impaired eye movements, particularly for the antisaccade task. Less saccade research has been conducted in relation to the broader schizophrenia continuum, that is, people with high schizoty...
7 Citations Source Cite
Published on Jul 9, 2015in Seminars in Hearing
Daniel L. Murman14
Estimated H-index: 14
(University of Nebraska Medical Center)
This article reviews the cognitive changes that occur with normal aging, the structural and functional correlates of these cognitive changes, and the prevalence and cognitive effects of age-associated diseases. Understanding these age-related changes in cognition is important given our growing elderly population and the importance of cognition in maintaining functional independence and effective communication with others. The most important changes in cognition with normal aging are declines in ...
35 Citations Source Cite
Published on Apr 1, 2015in Schizophrenia Research 3.96
Allen D. Radant35
Estimated H-index: 35
(University of Washington),
Steve P. Millard19
Estimated H-index: 19
+ 21 AuthorsRuben C. Gur111
Estimated H-index: 111
(University of Pennsylvania)
Abstract The impaired ability to make correct antisaccades (i.e., antisaccade performance) is well documented among schizophrenia subjects, and researchers have successfully demonstrated that antisaccade performance is a valid schizophrenia endophenotype that is useful for genetic studies. However, it is unclear how the ascertainment biases that unavoidably result from recruitment differences in schizophrenia subjects identified in family versus case–control studies may influence patient–control...
6 Citations Source Cite
Published on Sep 1, 2014in Schizophrenia Bulletin 6.94
James L. Reilly25
Estimated H-index: 25
(Northwestern University),
Kyle Frankovich1
Estimated H-index: 1
(University of California, Davis)
+ 6 AuthorsJohn A. Sweeney88
Estimated H-index: 88
(University of Texas Southwestern Medical Center)
Background: Elevated antisaccade error rate, reflecting problems with inhibitory behavioral control, is a promising intermediate phenotype for schizophrenia. Here, we consider whether it marks liability across psychotic disorders via common or different neurophysiological mechanisms and whether it represents a neurocognitive risk indicator apart from the generalized cognitive deficit. Methods: Schizophrenia (n = 267), schizoaffective (n = 150), and psychotic bipolar (n = 202) probands, their fir...
34 Citations Source Cite
Published on Sep 1, 2014in Schizophrenia Research: Cognition
Sohee Park43
Estimated H-index: 43
(Vanderbilt University),
Diane C. Gooding28
Estimated H-index: 28
(University of Wisconsin-Madison)
This review focuses on the viability of working memory impairment as an endophenotypic marker of a schizophrenia diathesis. It begins with an introduction of the construct of working memory. It follows with a consideration of the operational criteria for defining an endophenotype. Research findings regarding the working memory performance of schizophrenia and schizophrenia-spectrum patients, first-degree relatives of schizophrenia patients and healthy controls, are reviewed in terms of the crite...
47 Citations Source Cite
Published on Sep 1, 2013in Neuropsychiatric Disease and Treatment 2.19
Juliana Bittencourt8
Estimated H-index: 8
Bruna Velasques15
Estimated H-index: 15
+ 7 AuthorsPedro Ribeiro15
Estimated H-index: 15
Objective The study presented here analyzed the patterns of relationship between oculomotor performance and psychopathology, focusing on depression, bipolar disorder, schizophrenia, attention-deficit hyperactivity disorder, and anxiety disorder.
17 Citations Source Cite
Published on Jan 1, 2012in Handbook of experimental pharmacology
Richard S.E. Keefe81
Estimated H-index: 81
(Duke University),
Mark R. Serper Philip D. Harvey and Mich84
Estimated H-index: 84
(University of Miami)
Cognitive functioning is moderately to severely impaired in patients with schizophrenia. This impairment is the prime driver of the significant disabilities in occupational, social, and economic functioning in patients with schizophrenia and an important treatment target. The profile of deficits in schizophrenia includes many of the most important aspects of human cognition: attention, memory, reasoning, and processing speed. While various efforts are under way to identify specific aspects of ne...
224 Citations Source Cite
Published on Nov 1, 2011in Brain and Cognition 2.57
Shahrzad Mazhari10
Estimated H-index: 10
(University of Western Australia),
Greg Price7
Estimated H-index: 7
(University of Western Australia)
+ 3 AuthorsAssen Jablensky55
Estimated H-index: 55
(University of Western Australia)
Abstract Poor performance on the antisaccade task has been proposed as a candidate endophenotype in schizophrenia. Caveats to this proposal, however, include inconsistent findings in first-degree relatives of individuals with schizophrenia, and substantial heterogeneity in individuals with the disorder. In this study, we examined antisaccade performance in patients and relatives, and sought to establish whether antisaccade measures could differentiate between two patients clusters identified in ...
16 Citations Source Cite
Published on Aug 1, 2009in Archives of General Psychiatry
Michael J. Minzenberg31
Estimated H-index: 31
A. R. Laird66
Estimated H-index: 66
(University of Texas Health Science Center at San Antonio)
+ 2 AuthorsDavid C. Glahn76
Estimated H-index: 76
(Yale University)
Context:Prefrontalcorticaldysfunctionisfrequentlyreported in schizophrenia. It remains unclear whether this representsthecoincidenceofseveralprefrontalregion-and process-specific impairments or a more unitary dysfunctioninasuperordinatecognitivecontrolnetwork.Whether theseimpairmentsareproperlyconsideredreflectiveofhypofrontality vs hyperfrontality remains unresolved. Objectives: To test whether common nodes of the cognitivecontrolnetworkexhibitalteredactivityacrossfunctionalneuroimagingstudieso...
655 Citations Source Cite
Published on Aug 1, 2009in Psychiatry Research-neuroimaging 2.22
Jolanta Zanelli13
Estimated H-index: 13
James H. MacCabe29
Estimated H-index: 29
+ 3 AuthorsRobin M. Murrayand143
Estimated H-index: 143
Impairments on neuropsychological and eye movement tasks have been demonstrated in schizophrenic patients and also reported in their unaffected relatives. However, it is not clear to what extent these phenotypes overlap. This study examined the relationship between specific eye movement and neuropsychological measures. The relationship between performance on eye movement and neuropsychological tasks was measured in 79 schizophrenic patients (63% from multiply affected families), 129 of their hea...
9 Citations Source Cite
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