A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia
Abstract
Disrupted-in-schizophrenia 1 (DISC1) is strongly associated with schizophrenia, but it remains elusive how the modification of the intermolecular interaction of DISC1 affects the information processing in brain. We show that a DISC1 point mutation alters intermolecular cohesiveness promoting the phase separation, and disrupts sensorimotor gating monitored by the prepulse inhibition in a mouse model of schizophrenia. Although the conformation of...
Paper Details
Title
A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia
Published Date
Dec 18, 2018
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