Thrombin generation assay for testing hemostatic effect of factor VIII concentrates in patients with hemophilia A and inhibitors: In vitro results from the PredicTGA study

•The effect of VWF on FVIII concentrates is debated. •FVIII concentrates with or without VWF were added to hemophilic plasma and inhibitors. •Thrombin generation (TG) was measured before/after addition of concentrates. •FVIII inhibitor reactivity was assessed against each of the FVIII concentrates. •FVIII/VWF was the least reactive to inhibitors and the most efficient in...