Synthesis and olfactory properties of Phantolide analogues in racemic and optically active forms

The racemates, ( + )‐ and ( – )‐enantiomers, of eight novel Phantolide analogues, which are non‐natural musk odorants, were synthesized. The key step of the asymmetric synthesis was the lipase‐catalysed enantioselective transesterification of a racemic primary alcohol, and the resultant two enantiomers of the primary alcohol were used as intermediates for further transformations. The odour profiles of all of the synthesized Phantolide analogues...