l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans

Volume: 129, Issue: 1, Pages: 373 - 387
Published: Dec 10, 2018
Abstract
BACKGROUND.l-Carnitine, an abundant nutrient in red meat, accelerates atherosclerosis in mice via gut microbiota–dependent formation of trimethylamine (TMA) and trimethylamine N-oxide (TMAO) via a multistep pathway involving an atherogenic intermediate, γ-butyrobetaine (γBB). The contribution of γBB in gut microbiota–dependent l-carnitine metabolism in humans is unknown. METHODS. Omnivores and vegans/vegetarians ingested deuterium-labeled...
Paper Details
Title
l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans
Published Date
Dec 10, 2018
Volume
129
Issue
1
Pages
373 - 387
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