Genome-edited baby claim provokes international outcry

Published on Nov 1, 2018in Nature43.07
· DOI :10.1038/d41586-018-07545-0
David Cyranoski3
Estimated H-index: 3
Heidi Ledford Hkl24
Estimated H-index: 24
The startling announcement by a Chinese scientist represents a controversial leap in the use of genome editing. The startling announcement by a Chinese scientist represents a controversial leap in the use of genome-editing.
  • References (0)
  • Citations (40)
📖 Papers frequently viewed together
5,693 Citations
31 Authors (Hong Ma, ..., Shoukhrat Mitalipov)
328 Citations
11 Authors (Le Cong, ..., Feng Zhang)
6,987 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
Cited By40
This essay explores topic-specific inclusive frameworks and classroom approaches for genetics concepts related to gender identity, disability, and race.
Introduction: Cardiovascular disease (CVD) is a leading cause of morbidity and mortality. High plasma low-density lipoprotein cholesterol (LDL-C) levels are a key CVD-risk factor. Triglyceride-rich remnant particles and lipoprotein(a) (Lp[a]) are also causally related to CVD. Consequently, therapeutic strategies for lowering LDL-C and triglyceride levels are widely used in routine clinical practice; however, specific Lp(a) lowering agents are not available. Many patients do not achieve guideline...
#1A. Ivasilevitch (Université Paris-Saclay)
Last. Philippe Charlier (Université Paris-Saclay)H-Index: 10
view all 2 authors...
Resume Dans cet article, nous poursuivons notre reflexion entreprise dans une precedente contribution sur la medicalisation de la reproduction humaine, tendant a eviter la naissance d’enfants malades ou handicapes. Nous aborderons ici le probleme a la lueur d’un principe de procreation responsable, qui selon nous permet de saisir au mieux la realite des situations procreatives. Qu’une affection grave ait ete diagnostiquee sur un embryon, face a quels dilemmes sont confrontes les geniteurs ? Apre...
#1Rajeev K. Tyagi (VUMC: Vanderbilt University Medical Center)
#2Jing Li (VUMC: Vanderbilt University Medical Center)
Last. Jeremy A. GoettelH-Index: 17
view all 6 authors...
Abstract The immune system is quite remarkable having both the ability to tolerate innocuous and self-antigens while possessing a robust capacity to recognize and eradicate infectious pathogens and foreign entities. The genetics that encode this delicate balancing act include multiple genes and specialized cell types. Over the past several years, whole exome and whole genome sequencing has uncovered the genetics driving many human immune-mediated diseases including monogenic disorders and hemato...
1 CitationsSource
#1Joel Henrique Ellwanger (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 6
#2Valéria de Lima Kaminski (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 3
Last. José Artur Bogo Chies (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 24
view all 5 authors...
The CCR5 molecule was reported in 1996 as the main HIV-1 co-receptor. In that same year, the CCR5Delta32 genetic variant was described as a strong protective factor against HIV-1 infection. These findings led to extensive research regarding the CCR5, culminating in critical scientific advances, such as the development of CCR5 inhibitors for the treatment of HIV infection. Recently, the research landscape surrounding CCR5 has begun to change. Different research groups have realized that, since CC...
Rapid advances in technologies in the field of genomics such as high throughput DNA sequencing, big data processing by machine learning algorithms and gene-editing techniques are expected to make precision medicine and gene-therapy a greater reality. However, this development will raise many important new issues, including ethical, moral, social and privacy issues. The field of exercise genomics has also advanced by incorporating these innovative technologies. There is therefore an urgent need f...
#1Lydia Teboul (Medical Research Council)H-Index: 17
#2Yann Herault (UDS: University of Strasbourg)H-Index: 35
Last. Guillaume Pavlovic (UDS: University of Strasbourg)H-Index: 16
view all 5 authors...
Abstract Genome editing tools have already revolutionised biomedical research and are also expected to have an important impact in the clinic. However, their extensive use in research has revealed much unpredictability, both off- and on-target, in the outcome of their application. We discuss the challenges associated with this unpredictability, both for research and in the clinic. For the former, an extensive validation of the model is essential. For the latter, potential unpredicted activity do...
In der ethischen und rechtlichen Debatte um den moglichen Einsatz neuer Techniken zur Genomeditierung spielt der Begriff der genetischen Veranderung eine zentrale Rolle. Wahrend im Bereich der grunen Gentechnik intensive Debatten um seine Bedeutung gefuhrt werden, wird dieser Umstand im Kontext gentechnischer Interventionen am Menschen weitgehend ausgeblendet. Der Aufsatz expliziert drei mogliche Bedeutungen genetischer Veranderung, namentlich: ein prozessuales, ein diachrones sowie ein klassenb...
#1Giovanni BonioloH-Index: 11
#2Raffaella CampanerH-Index: 2
Last. Raffaella CampanerH-Index: 5
view all 2 authors...
Following recent debate on the relations between philosophy of science and the sciences, we wish to draw attention to some actual ways of training both young philosophers of science and young life scientists and clinicians. First, we recall a successful case of training philosophers of the life sciences in a strictly scientific environment. Second, after a brief review of the reasons why life scientists and clinicians are currently asking for more ethics, more methodology of science, and more ph...