Optimization of ionic liquid-incorporated PLGA nanoparticles for treatment of biofilm infections

Ionic liquids (ILs) containing imidazolium cations have a number of useful properties, such as high permeability to cells, high antimicrobial activity, and good biocompatibility. With the aid of ILs, transdermal delivery, solubilization of poorly soluble drugs were developed and therapeutic effects were improved. In this work, 1‑butyl‑3‑methylimidazolium hexafluorophosphate-incorporated, chitosan-modified, submicron-sized...