Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments
Abstract
Accumulation of trimethylation of histone H3 at lysine 4 (H3K4me3) on immune-related gene promoters underlies robust transcription during trained immunity. However, the molecular basis for this remains unknown. Here we show three-dimensional chromatin topology enables immune genes to engage in chromosomal contacts with a subset of long noncoding RNAs (lncRNAs) we have defined as immune gene-priming lncRNAs (IPLs). We show that the prototypical...
Paper Details
Title
Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments
Published Date
Dec 10, 2018
Journal
Volume
51
Issue
1
Pages
138 - 150
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