The effect of transcutaneous auricular vagus nerve stimulation on treatment-resistant depression monitored by resting-state fMRI and MRS: The first case report

Major depressive disorder (MDD) has a high prevalence rate and constitutes a leading cause of disability worldwide. Although there are various antidepressants available, approximately 35% of patients still can not achieve remission and progress to treatment-resistant depression (TRD) [ [1] Rush A.J. Trivedi M.H. Wisniewski S.R. Nierenberg A.A. Stewart J.W. Warden D. et al. Acute and longer–term outcomes in depressed outpatients requiring one or...