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ZnO Nanoparticles Modified with an Amphipathic Peptide Show Improved Photoprotection in Skin

Published on Jan 9, 2019in ACS Applied Materials & Interfaces8.46
· DOI :10.1021/acsami.8b08431
Anusha Aditya2
Estimated H-index: 2
(AcSIR: Academy of Scientific and Innovative Research),
Sabyasachi Chattopadhyay2
Estimated H-index: 2
(Institute of Genomics and Integrative Biology)
+ 7 AuthorsMunia Ganguli14
Estimated H-index: 14
(AcSIR: Academy of Scientific and Innovative Research)
Abstract
ZnO nanoparticles of different sizes were functionalized with an amphipathic peptide, and its effect on nanoparticle stabilization and UV photoprotective activity was studied in this article. The peptide-modified nanoparticles exhibited lower aggregation, significant reduction in Zn2+ leaching in vitro and even inside the cells for smaller particle sizes, reduced photocatalytic activity, and reduced cellular toxicity under UV-B treated conditions. In addition, the peptide-modified 60 nm ZnO nanoparticles showed lower genotoxicity, lower oxidative stress induction levels, less DNA damage responses, and less immunogenic potential than the bare counterparts in the presence of UV-B rays. They localized more in the stratum corneum and epidermis ex vivo, indicating better retention in epidermis, and demonstrated improved UV-B protection and/or skin integrity in SKH-1 mice in vivo compared to unmodified nanoparticles and commercial UV-protective agents tested. To our knowledge, this is the first report on the ap...
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#1Wei Ma (Jiangnan University)H-Index: 36
#2Lin Li (Jiangnan University)H-Index: 6
Last.Tung-Shi Huang (AU: Auburn University)H-Index: 25
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Last.Fabio CucinottaH-Index: 12
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