Human cardiomyocytes undergo enhanced maturation in embryonic stem cell-derived organoid transplants
Abstract
Human cardiomyocytes (CM) differentiated from pluripotent stem cells (PSCs) are relatively immature when generated in two-dimensional (2D) in vitro cultures, which limits their biomedical applications. Here, we devised a strategy to enhance maturation of human CM in vitro by assembly of three-dimensional (3D) cardiac organoids (CO) containing human embryonic stem cell-derived cardiac progenitor cells (hESC-CPCs), endothelial cells (ECs), and...
Paper Details
Title
Human cardiomyocytes undergo enhanced maturation in embryonic stem cell-derived organoid transplants
Published Date
Feb 1, 2019
Journal
Volume
192
Pages
537 - 550
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History