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Effectiveness of online interventions in preventing depression: a protocol for systematic review and meta-analysis of randomised controlled trials

Published on Nov 1, 2018in BMJ Open2.376
· DOI :10.1136/bmjopen-2018-022012
Alina Rigabert3
Estimated H-index: 3
(LUC: Loyola University Chicago),
Emma Motrico12
Estimated H-index: 12
(LUC: Loyola University Chicago)
+ 4 AuthorsJuan Ángel Bellón19
Estimated H-index: 19
Sources
Abstract
Introduction Although evidence exists for the efficacy of psychosocial interventions in preventing depression, little is known about its prevention through online interventions. The objective of this study is to conduct a systematic review and meta-analysis of randomised controlled trials assessing the effectiveness of online interventions in preventing depression in heterogeneous populations. Methods and analysis We will conduct a systematic review and meta-analysis of randomised controlled trials that will be identified through searches of PubMed, PsycINFO, WOS, Scopus, OpenGrey, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and Australia New Zealand Clinical Trials Register . We will also search the reference lists provided in relevant studies and reviews. Experts in the field will be contacted to obtain more references. Two independent reviewers will assess the eligibility criteria of all articles, extract data and determine their risk of bias (Cochrane Collaboration Tool). Baseline depression will be required to have been discarded through standardised interviews or validated self-reports with standard cut-off points. The outcomes will be the incidence of new cases of depression and/or the reduction of depressive symptoms as measured by validated instruments. Pooled standardised mean differences will be calculated using random-effect models. Heterogeneity and publication bias will be estimated. Predefined sensitivity and subgroup analyses will be performed. If heterogeneity is relevant, random-effect meta-regression will be performed. Ethics and dissemination The results will be disseminated through peer-reviewed publication and will be presented at a professional conference. Ethical assessment is not required as we will search and assess existing sources of literature. Trial registration number CRD42014014804; Results.
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References47
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#1Mark Deady (Black Dog Institute)H-Index: 9
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#1Jin Young Nam (Yonsei University)H-Index: 3
#2Juyeong Kim (Yonsei University)H-Index: 3
Last. Eun-Cheol Park (Yonsei University)H-Index: 31
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#1Ting Zhou (Beijing University of Chinese Medicine)H-Index: 1
#2Xue Li (Beijing University of Chinese Medicine)H-Index: 1
Last. Junhui Kong (Beijing University of Chinese Medicine)H-Index: 1
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#1Lasse SanderH-Index: 5
#2Leonie RauschH-Index: 2
Last. Harald BaumeisterH-Index: 30
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#1Claudia Buntrock (VU: VU University Amsterdam)H-Index: 8
#2David Daniel EbertH-Index: 34
Last. Pim Cuijpers (VU: VU University Amsterdam)H-Index: 104
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#1Siew Ching Ho (Universiti Sains Malaysia)H-Index: 2
#2Huey Yi Chong (Monash University Malaysia Campus)H-Index: 8
Last. Sabrina Anne Jacob (Monash University Malaysia Campus)H-Index: 6
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#1Caroline FairhurstH-Index: 9
#2Kerry BellH-Index: 5
Last. David TappinH-Index: 77
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#1Pim Cuijpers (UvA: University of Amsterdam)H-Index: 104
#2Ioana A. CristeaH-Index: 18
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