SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice

Energy homeostasis is regulated by the hypothalamus but fails when animals are fed a high-fat diet (HFD), and leptin insensitivity and obesity develops. To elucidate the possible mechanisms underlying these effects, a microarray-based transcriptomics approach was used to identify novel genes regulated by HFD and leptin in the mouse hypothalamus.Mouse global array data identified serpinA3N as a novel gene highly upregulated by both a HFD and...