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L-Carnitine Supplementation Increases Trimethylamine-N-Oxide but not Markers of Atherosclerosis in Healthy Aged Women

Published on Jan 1, 2019in Annals of Nutrition and Metabolism3.051
· DOI :10.1159/000495037
Joanna J. Samulak1
Estimated H-index: 1
,
Angelika K. Sawicka2
Estimated H-index: 2
+ 4 AuthorsRobert A. Olek12
Estimated H-index: 12
Abstract
  • References (0)
  • Citations (3)
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Last. Aouatef BellamineH-Index: 4
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Trimethylamine-N-oxide (TMAO) is generated in a microbial-mammalian co-metabolic pathway mainly from the digestion of meat-containing food and dietary quaternary amines such as phosphatidylcholine, choline, betaine, or L-carnitine. Fish intake provides a direct significant source of TMAO. Human observational studies previously reported a positive relationship between plasma TMAO concentrations and cardiometabolic diseases. Discrepancies and inconsistencies of recent investigations and previous s...
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#2Jane ChalmersH-Index: 1
Last. Guruprasad P. AithalH-Index: 40
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L-carnitine supplementation in non-alcoholic fatty liver disease: A systematic review and meta-analysis
1 CitationsSource
l-carnitine supplementation has been used for cardiovascular health protection for a long time. Recently, trimethylamine-N-oxide (TMAO), which is an end product of l-carnitine metabolism via the activity of microbiota, has been identified as a cardiovascular disease (CVD) biomarker. The aim of this study was to assess the effect of 6 months of l-carnitine supplementation in a group of aged women engaged in a regular physical training. Platelet mitochondrial DNA methylation, an emerging and innov...
1 CitationsSource
#1Shengjie YangH-Index: 1
#2Xinye Li (Beijing University of Chinese Medicine)H-Index: 2
Last. Min WuH-Index: 1
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Cardiovascular disease (CVD) is the leading cause of death worldwide, especially in developed countries, and atherosclerosis (AS) is the common pathological basis of many cardiovascular diseases (CVDs) such as coronary heart disease (CHD). The role of the gut microbiota in AS has begun to be appreciated in recent years. Trimethylamine N-oxide (TMAO), an important gut microbe-dependent metabolite, is generated from dietary choline, betaine, and L-carnitine. Multiple studies have suggested a corre...
6 CitationsSource
Increased plasma trimethylamine N-oxide (TMAO) levels have been associated with cardiovascular diseases (CVD). L-carnitine induces TMAO elevation in human blood, and thus, it has been suggested as developing atherosclerosis. The aim of this study was to determine the relation between selected markers of oxidative stress and plasma TMAO concentration induced by L-carnitine supplementation for 24 weeks in healthy aged women. Twenty aged women were supplemented during 24 weeks with either 1500 mg L...
2 CitationsSource
#1Sarah M. MitchellH-Index: 5
#2Amber M. MilanH-Index: 5
Last. David Cameron-SmithH-Index: 48
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Higher dietary protein intake is increasingly recommended for the elderly; however, high protein diets have also been linked to increased cardiovascular disease (CVD) risk. Trimethylamine-N-oxide (TMAO) is a bacterial metabolite derived from choline and carnitine abundant from animal protein-rich foods. TMAO may be a novel biomarker for heightened CVD risk. The purpose of this study was to assess the impact of a high protein diet on TMAO. Healthy men (74.2 ± 3.6 years, n = 29) were randomised to...
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#1Frédéric Leroy (Vrije Universiteit Brussel)H-Index: 38
#2Nathan Cofnas (University of Oxford)H-Index: 5
AbstractMainstream dietary recommendations now commonly advise people to minimize the intake of red meat for health and environmental reasons. Most recently, a major report issued by the EAT-Lancet...
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#1Joanna J. SamulakH-Index: 1
Last. Robert A. OlekH-Index: 12
view all 4 authors...
L-carnitine supplementation elevates plasma trimethylamine-N-oxide (TMAO), which may participate in atherosclerosis development by affecting cholesterol metabolism. The aim of the current study was to determine the effect of increased plasma TMAO on biochemical markers in the blood following cessation of L-carnitine supplementation. The follow-up measurements were performed on subjects who completed 24 weeks of L-carnitine or placebo supplementation protocol. Blood samples were taken after finis...
1 CitationsSource