Generation of a highly efficient and tissue-specific tryptophan hydroxylase 1 knockout mouse model

Volume: 8, Issue: 1
Published: Dec 5, 2018
Abstract
Recent studies on tissue-autonomous serotonin (5-hydroxytryptamine [5-HT]) function have identified new roles for 5-HT in peripheral organs. Most of these studies were performed by crossing mice carrying the Tph1 tm1Kry allele with tissue specific Cre mice. In the present study, we found that 5-HT production was not completely abolished in Tph1 tm1Kry KO mice. The residual 5-HT production in Tph1 tm1Kry KO mice is attributed to the expression of...
Paper Details
Title
Generation of a highly efficient and tissue-specific tryptophan hydroxylase 1 knockout mouse model
Published Date
Dec 5, 2018
Volume
8
Issue
1
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