Overcoming chemotherapy resistance via simultaneous drug-efflux circumvention and mitochondrial targeting
Abstract
Multidrug resistance (MDR) has been considered as a huge challenge to the effective chemotherapy. Therefore, it is necessary to develop new strategies to effectively overcome MDR. Here, based on the previous research of N-(2-hydroxypropyl)methacrylamide (HPMA) polymer–drug conjugates, we designed an effective system that combined drug-efflux circumvention and mitochondria targeting of anticancer drug doxorubicin (Dox). Briefly, Dox was modified...
Paper Details
Title
Overcoming chemotherapy resistance via simultaneous drug-efflux circumvention and mitochondrial targeting
Published Date
May 1, 2019
Journal
Volume
9
Issue
3
Pages
615 - 625
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Notes
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