Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis

Rare genetic variants cause pulmonary arterial hypertension, but the contribution of common genetic variation to disease risk and natural history is poorly characterised. We tested for genome-wide association for pulmonary arterial hypertension in large international cohorts and assessed the contribution of associated regions to outcomes.We did two separate genome-wide association studies (GWAS) and a meta-analysis of pulmonary arterial...