Oncolytic herpes simplex virus tumor targeting and neutralization escape by engineering viral envelope glycoproteins
Abstract
Oncolytic herpes simplex viruses (oHSVs) have been approved for clinical usage and become more and more popular for tumor virotherapy. However, there are still many issues for the oHSVs used in clinics and clinical trials. The main issues are the limited anti-tumor effects, intratumor injection, and some side effects. To overcome such challenges, here we review the genetic engineering of the envelope glycoproteins for oHSVs to target tumors...
Paper Details
Title
Oncolytic herpes simplex virus tumor targeting and neutralization escape by engineering viral envelope glycoproteins
Published Date
Jan 1, 2018
Journal
Volume
25
Issue
1
Pages
1950 - 1962
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